Pharmacokinetics and bronchial diffusion of single daily dose amikacin in cystic fibrosis patients
نویسندگان
چکیده
منابع مشابه
Influence of sepsis on higher daily dose of amikacin pharmacokinetics in critically ill patients.
BACKGROUND AND OBJECTIVES Severe sepsis is a major problem as cause of high rates morbidity and mortality in intensive care units (ICU). Aminoglycosides are an important group of antimicrobials used for severe sepsis. However, aminoglycoside pharmacokinetics in ICU patients may be altered during sepsis, which can affect the drug concentrations. Therefore, this study was undertaken to examine th...
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Cystic fibrosis (CF) is a recessive genetic disease characterised by impaired muco-ciliary clearance. Although the disease affects multiple organs, 85% of mortality results from lung pathology relating to persistent recurrent infections, an exaggerated inflammatory response and progressive airways obstruction which ultimately leads to respiratory failure. Haemoptysis is a common symptom of CF w...
متن کاملPharmacokinetics of once and twice daily dosing of intravenous tobramycin in paediatric patients with cystic fibrosis.
The optimal dosing of intravenous tobramycin for treatment of pulmonary exacerbations in paediatric cystic fibrosis (CF) patients has not been completely delineated. We performed a retrospective study evaluating the pharmacokinetics and pharmacodynamics of once daily dosing (ODD) of IV tobramycin compared to twice daily dosing (TDD). Fifty-nine and 44 patients were included in the ODD and TDD g...
متن کاملPopulation pharmacokinetics of high dose ibuprofen in cystic fibrosis.
AIMS To evaluate ibuprofen population pharmacokinetics in a large series of data collected in children with cystic fibrosis (CF) treated with high doses of ibuprofen (59 patients; 2-18 years), and to identify the main causes responsible for the considerable interindividual variability in ibuprofen serum levels. METHODS Blood samples were collected during routine clinical care; serum ibuprofen...
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Amikacin is a bactericidal aminoglycoside. Aminoglycosides inhibit bacterial protein synthesis. The antibacterial spectrum of amikacin is the broadest of aminoglycosides. Because of its resistance to many of the aminoglycosides-inactivating enzymes, it has a special role in hospitals where gentamicin- and tobramycin-resistant microorganisms are prevalent. Amikacin is active against the majority...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1997
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/39.3.431